Universität Bayreuth

Lehrstuhl Biopolymere

PD Dr. Ute C. Marx Diplom-Chemikerin

Telefon             ++61 7 3346 2925
Telefax             ++61 7 3346 2101
E-Mail              ute.marx(at)uni-bayreuth.de or u.marx(at)imb.uq.edu.au        (at) = @
Present address     Institute for Molecular Bioscience
                    University of Queensland
                    4072 St. Lucia, QLD, Australia

Areas of research interest of Dr. Ute C. Marx:

• parathyroid hormone (PTH)
• uroguanylin and guanylin
• proguanylin
• LEKTI fragments

Publications:

1. "Structure of Human Parathyroid Hormone 1-37 in Solution"; U. C. Marx, S. Austermann, P. Bayer, K. Adermann, A. Ejchart, H. Sticht, S. Walter, F.-X. Schmid, R. Jaenicke, W.-G. Forssmann & P. Rösch (1995) J. Biol. Chem. 270, 15194-15202.

   
   

2. "NMR studies in relation to biological effects: Investigations on the structure-activity relationship of human parathyroid hormone (hPTH)". W.-G. Forssmann, U. Marx, P. Bayer, K. Adermann, D. Hock & P. Rösch (1996) Peptides: Chemistry, Structure and Biology (P. T. Kaumaya & R. S. Hodges, eds.) Mayflower Scientific Ltd., UK, pp. 225-226.

   
   

3. "Synthesis of Human Guanylin: Temperature-dependent HPLC, CZE and NMR Studies verify Stereoisomerism of a Disulfide-containing Peptide". K. Adermann, S. Neitz, U. C. Marx, P. Rösch & W.-G. Forssmann (1996) Innovations and Perspektives in Solid Phase Synthesis and Combinatorial Chemical Libraries (R. Epton, ed.) Mayflower Scientific Ltd., UK, pp. 299-302.

   
   

4. "Synthesis, Biological Activity and Isomerism of Guanylate Cyclase C-Activating Peptides Guanylin and Uroguanylin". J. Klodt, M. Kuhn, U. C. Marx, S. Martin, P. Rösch, W.-G. Forssmann & K. Adermann (1997) J. Peptide Res. 50, 222-230.

   
   

5. "Structure-Activity Relation of NH₂-Terminal Human Parathyroid Hormone Fragments". U. C. Marx, K. Adermann, P. Bayer, M. Meyer, W.-G. Forssmann & P. Rösch (1998) J. Biol. Chem. 273, 4308-4316.

   
   

6. "One Peptide, Two Topologies: Structure and Interconversion Dynamics of Human Uroguanylin Isomers". U. C. Marx, J. Klodt, M. Meyer, H. Gerlach, P. Rösch, W.-G. Forssmann & K. Adermann (1998) J. Pept. Res. 52, 229-240.

   
   

7. "Carboxy-terminal extension stabilizes the topological stereoisomers of guanylin". A. Schulz, S. Escher, U. C. Marx, M. Meyer, P. Rösch, W.-G. Forssmann & K. Adermann (1998) J. Pept. Res. 52, 518-525.

   
   

8. "The Structure of Human Parathyroid-Hormone-Related Protein(1-34) in Near-Physiological Solution". M. Weidler, U. C. Marx, G. Seidel, W. Schäfer, E. Hoffmann, A. Esswein & P. Rösch (1999) FEBS Letters 444, 239-244.

   
   

9. "Role of the Prosequence of Guanylin". A. Schulz, U. C. Marx, Y. Hidaka, Y. Shimonishi, P. Rösch, W.-G. Forssmann & K. Adermann (1999) Prot. Sci. 8, 1850-1859.

   
   

10. "Isolation, Purification and Characterization of Human Proguanylin: Comparison of the Native and Recombinant Protein". A. Schulz, U. C. Marx, P. Rösch, W.-G. Forssmann & K. Adermann (1999) Peptides 1998, Proceedings of the 25th. European Peptide Symposium (S. Bajusz & F. Hudecz, eds.) Akademiai Kiado, Budapest, Hungary, pp. 326-327.

    
    

11. "Structure-Activity Relationship and Design of Stabilized Guanylin Stereoisomers". S. Escher, A. Schulz, U. C. Marx, P. Rösch, W.-G. Forssmann & K. Adermann (1999) Peptides 1998, Proceedings of the 25th. European Peptide Symposium (S. Bajusz & F. Hudecz, eds.) Akademiai Kiado, Budapest, Hungary, pp. 416-417.

    
    

12. "Solution Structures of Human Parathyroid Hormone Fragments hPTH(1-34) and hPTH(1-39) and Bovine Parathyroid Hormone Fragment bPTH(1-37)". U. C. Marx, K. Adermann, P. Bayer, W.-G. Forssmann & P. Rösch (2000) Biochem. Biophys. Res. Commun. 267, 213-220.

    
    

13. "Structures of Human Peptide Hormones in Solution". U. Marx, K. Adermann, A. Schulz, M. Meyer, W.-G. Forssmann & P. Rösch (2001) in: Nato ASI Series (O. Jardetzky, ed.), Life Sciences, 315, pp. 145 - 161.

    
    

14. "Receptor Recognition by a Hepatitis B Virus Reveals a Novel Mode of High Affinity Virus-Receptor Interaction". S. Urban, C. Schwarz, U. C. Marx, H. Zentgraf, H. Schaller & G. Multhaup (2000) EMBO J. 19, 1217-1227.

    
    

15. "Accurate Disulfide Formation in E. coli: Overexpression and Characterization of the First Domain (HF6478) of the Multiple Kazal Type Inhibitor LEKTI". T. Lauber, U. C. Marx , A. Schulz, P. Kreutzmann, P. Rösch & S. Hoffmann (2001) Prot. Expr. Purif. 22, 108-112.

    
    

16. "Native and Recombinant Proguanylin Feature Identical Biophysical Properties and are Monomeric in Solution". T. Lauber, A. Nourse, A. Schulz & U. C. Marx (2002) Biochemistry 41, 14602-14612.

    
    

17. "Homologous Proteins with Different Folds: The Three-Dimensional Structures of Domains 1 and 6 of the Multiple Kazal-Type Inhibitor LEKTI". T. Lauber, A. Schulz, K. Schweimer, K. Adermann & U. C. Marx (2003) J. Mol. Biol. 328, 205-219.

    
    

18. "Enzymatic Cyclisation of the Potent Bowman-Birk Protease Inhibitor SFTI-1 and Solution Structure of an Acyclic Precursor Peptide". U. C. Marx, M. L. Korsinczky, H. J. Schirra, A. Jones, B. Condie, L. Otvos Jr. & D. J. Craik (2003) J. Biol. Chem. 278, 21782-21789.

    
    

19. "Solution Structure of Human Proguanylin: The Role of a Hormone Prosequence". T. Lauber, P. Neudecker, P. Rösch & U. C. Marx (2003) J. Biol. Chem. 278, 24118-24124.

    
    

20. "CD- and NMR-studies of prion protein helix 1: Novel implications for its role in the PrPC PrPSc conversion process". J. Ziegler, H. Sticht, U. C. Marx, W. Müller, P. Rösch & S. Schwarzinger (2003) J. Biol. Chem. 278, 50175-50181.

    
    

21. "Expression of LEKTI domains 6-9' in the baculovirus expression system: recombinant LEKTI domains 6-9' inhibit trypsin and subtilisin A". A. Jayakumar, Y. Kang, K. Mitsudo, Y. Henderson, M. J. Frederick, M. Wang, A. K. El-Naggar, U. C. Marx, K. Briggs & G. L. Clayman (2004) Prot. Expr. Purif. 35, 93-101.

    
    

22. "Role of disulfide bonds for the structure and folding of proguanylin". T. Lauber, A. Schulz, P. Rösch & U. C. Marx (2004) Biochemistry 43, 10050-10057.

    
    

23. "Prosequence-mediated disulfide coupled folding of the peptide hormones guanylin and uroguanylin". T. Lauber & U. C. Marx (2005) Protein Pept. Letters 12, 153-158.

    
    

24. "Side chain contributions to the interconversion of the topological isomers of guanylin-like peptides" A. Schulz, U. C. Marx, N. Tidten, T. Lauber, Y. Hidaka & K. Adermann, J. Pept. Science, in press.

    
    

25. "Solution structure of a chimeric LEKTI-domain reveals a chameleon sequence". H. Tidow, T. Lauber, K. Vitzithum, C. P. Sommerhoff, P. Rösch & U. C. Marx (2004) Biochemistry 43, 11238-11247.

    
    

Poster presentations