List of Publications
PD Dr. Stephan Schwarzinger


Publications in peer-reviewed journals

H.-G. Breitinger, N. Melzer, H. Rennert, U. Breitinger, S. Schwarzinger, C. Villmann, C.-M. Becker: A novel regulatory site within the TM 3-4 loop of recombinant human α3 glycine receptors: a remote control for channel gating and domain structure, submitted.

S. Schwarzinger, R. Mohana-Borges, G.J.A. Kroon, H.J. Dyson, P.E. Wright: Structural Characterization of Partially Folded Intermediates of Apomyoglobin H64F, Prot. Sci., in press.

J. Griese, R. Jakob, S. Schwarzinger, H. Dobbek (2006): Xenobiotic Reductase A in the Degradation of Quinoline by Pseudomonas putida 86: Physiological Function, Structure and Mechanism of 8-Hydroxycoumarin Reduction, J. Mol. Biol. 361, 140-152. 

S. Schwarzinger*, A. Horn, J. Ziegler, H.. Sticht (2006): Rare Large Scale Subdomain Motions in Prion Protein can Initiate Aggregation, J. Biomol. Struct. Dyn. 23, 581-590. 

J. Ziegler, C. Viehrig, S. Geimer, P. Rösch, S. Schwarzinger* (2006): Putative Aggregation Initiation Sitesin Prion Protein, FEBS Lett. 580, 2033-2040. 

J. Ziegler* & S. Schwarzinger*(2006): Genetic algorithms as a tool for helix design – computational and experimental studies on prion protein helix 1, J. Comp. Aided Mol. Design 20, 47-54. 

A. Eisenmann, P. Neudecker, P. Rösch, S. Schwarzinger* (2004): Treatment of Peak Intensity Uncertainties in NMR-Relaxation Data Analysis Can Lead to Severe Artifacts, Chemical Monthly (Monatshefte Chemie) 135, 1089-1099.

P. Neudecker, J. Nerkamp, A. Eisenmann, A. Nourse, T. Lauber, K. Schweimer, K. Lehmann, S. Schwarzinger, F. Ferreira, P. Rösch (2004): Solution Structure, Dynamics, and Hydrodynamics, of the Calcium-bound Cross-reactive Birch Pollen Allergen Bet v 4 Reveal a Cannonical Monomeric Two EF-Hand Assembly with a Regulatory Function,  J. Mol. Biol. 336, 1141-1157.

J. Ziegler, H. Sticht, U.C. Marx, W. Müller, P. Rösch, S. Schwarzinger* (2003): NMR and CD studies of prion protein helix 1: Novel implications for its role in the PrPC→PrPSc conversion process, J. Biol. Chem. 257, 50175-50181.

S. Schwarzinger, H. J. Dyson, P. E. Wright (2002): Molecular Hinges in Protein Folding: the Urea-Denatured State of Apomyoglobin, Biochemistry 41, 12681-12686.                   

S. Cavagnero, C. Nishimura, S. Schwarzinger, H. J. Dyson, P. W. Wright (2001): Conformational and Dynamical Characterization of the Molten Globule State of an Apomyoglobin Mutant with an Altered Folding Pathway, Biochemistry 40, 14459-14467.

J. H. Viles, B. M. Duggan, E. Zaborowski, S. Schwarzinger, H. J. Dyson, P. W. Wright (2001): Potential bias in NMR relaxation data introduced by peak intensity analysis of curve fitting methods, J. Biomol. NMR 21, 1-9.

S. Schwarzinger, G. J. A. Kroon, T. Foss, John Chung, P. E. Wright, H. J. Dyson (2001): Sequence Corrections for Random Coil Chemical Shifts, J. Am. Chem. Soc. 132, 2970-2978.

S. Schwarzinger, M. Hartmann, P. Kremminger, N. Müller (2001): Hydrophobic forms of morphine-6-glucosides; Bioorg. Med. Chem. Let. 11, 1455-1459.

S. Schwarzinger, G. J. A. Kroon, T. Foss, P. E. Wright, H. J. Dyson (2000): Random Coil Chemical Shifts in acidic 8 M Urea, J. Biomol. NMR 18, 43-48.

R. Grandori, S. Schwarzinger, N. Müller (2000): Cloning, Overexpression and Characterization of Micro-Myoglobin, a Minimal Heme-Binding Fragment, Eur. J. of Biochem. 267, 1168-1172.

S. Schwarzinger, W. Ahrer, N. Müller (2000): Proteolytic preparation of a heme binding fragment from sperm whale myoglobin: micro-myoglobin, Chemical Monthly 131, 409-416.

C. Etzlstorfer, H. Falk, E. Mayr, and S. Schwarzinger (1996): Concerning the Acidity and Hydrogenbonding of Hydroxyphenanthroperylene Quinones like Fringelite D, Hypericin, and Stentorin, Chemical Monthly 127, 1229-1237.

Book Chapters:

S. Schwarzinger, D. Willbold, J. Ziegler: Structural Studies of Prion Proteins, in: Prions in Humans and Animals. Eds: B. Hörnlimann, D. Riesner & H. Kretzschmar, W. De Gruyter, Berlin, New York, 2006.

 
Invited Talks and Oral Presentations

1)       "Prion Propagation: Novel Insights into Mechanism and Therapeutic Strategies", Institut für Biochemie, Erlangen, Mai 2006.

2)       "Rare subdomain motions in prion protein can initiate aggregation", Symposium Evolution of Biomolecular Structure, Wien, Mai 2006.

3)       "Bio-NMR: Struktur und Dynamik (gefalteter und) ungeordneter Proteine", Böhringer-Ingelheim GmbH, Biberach/Riß, September 2005.

4)       " Bio-NMR: Struktur und Dynamik (gefalteter und) ungeordneter Proteine ", Institut für Biomolekulare Optik, LMU, München, Dezember 2004.

5)       "Lessons from Urea-Denatured Proteins Studies by NMR-Spectroscopy", Tagung des Gradiertenkollegs  "Protein Interaktionen" der Universität Erlangen, Gosberg, Dezember 2004.

6)       "Advanced Processing and Assignment in Biomolecular NMR", NMR-Wintercourse, Nove Hrady, Februar 2004.

7)       "Evidence for Binding of Tricyclic Aromatic Compounds to Helix 1 of Prion Protein", 5th International Conference on Molecular Structural Biology, Wien, September 2003.

8)       "Residual Structure in Denatured Proteins Characterized by NMR", IMB-Symposium Protein Folding – Principles and Pathological Implications, IMP, Jena, September 2002.

9)       "Early Events in Protein-Folding: NMR-Studies of Urea Denatured Apomyoglobin", Clark-University, Worcester, MA, Juli 2002.

10)    "Einblicke in frühe Ereignisse der Proteinfaltung mittles NMR an ungefalteten Proteinen", Ruhr-Universität Bochum, Juni 2002.

11)    "Proteinfolding and NMR", TU Wien, September 2000.

12)    "NMR-Characterization of Urea-Unfolded Myoglobin", Universität Bayreuth, Oktober 2000.

 

Talks at Conferences and Meetings:

1)        "Seeking the right candidate – NMR in anti-prion drug development", Tagung der Volkswagen-Stiftung, Heidelberg , Oktober 2005.

2)        "Bindung von tricyclischen Aromaten an PrP-Helix 1", Bayerische Forschungsplattform ForPrion, München, Juli 2003.

3)        "NMR Studien zur Strukturumwandlung des Prion-Proteins - Fragment 110-157", Bayerische Forschungsplattform ForPrion, Wildbad-Kreuth, Juli 2002.

4)        "NMR Studien zur Strukturumwandlung des Prion-Proteins - Helix A", Deutsche TSE-Plattform, Berlin, Juni 2002.

5)    "NMR-Characterization of Urea-Unfolded Myoglobin", 9. Chemietage der Gesellschaft Österreichischer Chemiker, Innsbruck, September 2000.

Other publications:

    S. Schwarzinger & P. Rösch: 15N-HSQC at natural abundance for high-throughput screening, Bruker Biospin CryoProbe Spektrenkatalog (2002).


Fundings and Fellowships