Name:
Schwarzinger, Stephan, Prof. Dr.

Date of Birth:
January 21, 1970
Address:
Universität Bayreuth; Dept. of Biopolymers
Universitätsstraße 30, 95447 Bayreuth
Phone: +49 921 55-2046
Fax: +49 921 55-4368
Email: stephan.schwarzinger@uni-bayreuth.de

Current Position
from 2013 extra-curricular Professor, Dept. of Biopolymers and Research Center for Bio-Macromolecules, U Bayreuth

Education
1995 Diploma: Technical Chemistry with Bussiness Administration (WITECH), Linz
Diploma Thesis: Prof. N. Müller, Johannes Kepler Universität Linz

Scientific Grades
2007 Habilitation: Biophysical Chemistry, U Bayreuth
Thesis: Prof. P. Rösch, Department of Biopolymers, U Bayreuth
1999 Doctoral Degree: Technical Chemistry, U Linz
Thesis: Prof. N. Müller, Johannes Kepler Universität Linz

Career
from 2013 extra-curricular Professor, U Bayreuth
from 2012 Member of the Board of the Profile Field "Food and Health Sciences", U Bayreuth
from 2010 CEO ALNuMed GmbH (subsidiary office)
2011 Co-applicant 1 GHz NMR spectrometer, U Bayreuth
from 2010 Member of Research Center for Bio-Macromolecules (BIOmac), U Bayreuth
from 2008 Member of ENB study course "Macromolecular Science", U Bayreuth
2007 - 2013 Privatdozent, Department of Biopoylmers, U Bayreuth
2008 - 2012 Member of ENB Graduate School "Lead Structures of Cell Function", U Bayreuth
2008 - 2012 Project Leader DFG Project "Pathegenic Prion Conformers", U Bayreuth
2008 Professor (W3, interim), Department of Biochemistry, U Bayreuth
2008 Organizer of BaCaTeC Summer School "Structure in Biology – Key to Understanding", U Bayreuth
2006 - 2012 Coordinator ENB Graduate School "Lead Structures of Cell Function", U Bayreuth
2004 - 2008 Coordinator of VW-Foundation Project "Design of high affinity, conformation-specific ligands for pharmacotherapy of PrP-related diseases", U Bayreuth
2004 Organizer of the 1st BaCaTeC Summer School "NMR of Biomolecular Complexes", U Bayreuth
2001 - 2003 Co-Applicant ForPrion Project "Rational Design of Anti-Prion Substances", Department of Biopolymers, U Bayreuth
2000 - 2007 Group leader, Department of Biopolymers, U Bayreuth
1999 - 2000 Postdoctoral Fellow, The Scripps Research Institute, La Jolla, CA
1996 Research stay, European Molecular Biology Laboratory, Heidelberg

Additional Information
2002 Offer of the position of Assistant Research Professor, Clark Univeristy, Worchester, MA (rejected)

10 Important Publications
(Members of the Dept. of Biopolymers: boldface)
[1]     Härteis S, Schaal D, Brauer F, Brüschke S, Schweimer K, Rauh R, Sticht H,Rösch P, Schwarzinger S, Korbmacher C. An inhibitory peptide derived from the alpha subunit of the epithelial sodium channel (ENaC) shows a helical conformation. Cell. Physiol. Biochem. 2012 29, 761-774.
[2]     Hartl MJ, Burmann BM, Prasch SJ, Mangels, Kellner R, Schweimer K, Schwarzinger C, Rösch P, Schwarzinger S. Fast Mapping of biomolecular interfaces by random spin labeling (RSL). J. Biomol Struct. Dyn. 2012, 29, 793-8
[3]     Camillioni C, Schaal D, Schweimer K, Schwarzinger S, De Simone A. Energy Landscape of the Prion Protein Helix H1 Probed by Medadynamics and NMR. Biophys J. 2012 102, 158-67.
[4]     Kellner R, Mangels, Schweimer K, Prasch SJ, Weigelmeier PR, Rösch P, Schwarzinger S. SEMPRE: spectral editing mediated by paramagnetic relaxation enhancement. J. Am Chem. Soc. 2009 131, 18016-18017.
[5]     Mangels C, Frank AO, Ziegler J, Klingenstein R, Schweimer K, Willbold D, Korth C, Rösch P, Schwarzinger S. Binding of TCA to the prion protein: mechanism, implication for therapy, and application as a probe to detect complex formation of biomacromolecules by NMR-spectroscopy. J. Biomol. Struct. Dyn. 2009 27, 163-170.
[6]     Müller-Schiffmann A, Petsch B, Leliveld R, Muyrers J, Salwierz A, Mangels C, Schwarzinger S, Riesner D, Stitz L, CKorth C. Complementary determining regions of an anti-prion protein scFv fragment orchestrate conformation specificity and antiprion activity. Mol. Immunol. 2009 46, 532-540.
[7]     Schwarzinger S, Horn A, Ziegler J, Sticht H. Rare Large Scale Subdomain Motions in Prion Protein can Initiate Aggregation. J. Biomol. Struct. Dyn. 2006 23, 581-590.
[8]     Ziegler J, Sticht H, Marx UC, Müller W, Rösch P, Schwarzinger S. NMR and CD studies of prion protein helix 1: Novel implications for its role in the PrPc → PrPSc conversion process. J. Biol. Chem. 2003, 278, 50175-50181
[9]     Schwarzinger S, Dyson HJ, Wright PE. Molecular Hinges in Protein Folding: the Urea-Denatured State of Apomyoglobin. Biochemistry 2002, 41, 12681-12686
[10]     Schwarzinger S, Kroon GJA, Foss T, Chung J, Wright PE, Dyson HJ. Sequence Corrections for Random Coil Chemical Shifts. J. Am. Chem. Soc. 2001 132, 2970-2978.
Schwarzinger S, Mangels C. "Comb-Ign: NMR-spektroskopische Bestimmung von molekularen Kontaktflächen mittels eines kombinatorischen Verfahrens"; Patentanmeldung DPMA (Nr. 10 2008 024 054.0).
Schwarzinger S, Hofmann R. "Hq-NMR: Honey-quantitative NMR"; Eur. Patentanmeldung.

Research Interests
  • Protein-(mis)Folding, Aggregation, and Molecular Interactions.
  • Spectroscopy and Hyphenated Technologies.
  • Mixture-Analytics, Food-Analytics, Authenticity Testing.